Lorenzo Palmieri

PhD in Multiscale Modelling, Computational Simulations and Characterization in Material and Life Sciences Department of Information Engineering University of Modena and Reggio Emilia Via Vignolese 905 - 41126 Modena (Italy)   lorenzo.palmieri AT unimore.it

• Short Resume
• Research Activity
• Papers
• Workshops
• Conferences

Short Resume

Lorenzo Palmieri is currently an Attending Graduate at the "Molecular Modelling and Drug Design Laboratory", in the Pharmaceutical Sciences Department at the University of Modena and Reggio Emilia, following a project titled "Protein-protein interactions analysis for the design of interaction modulator molecules".

Lorenzo Palmieri is a Doctor of Philosophy (PhD) in Multiscale Modelling, Computational Simulations and Characterization in Material and Life Sciences, taken in 2012 at the University of Modena and Reggio Emilia. He completed the doctorate course with a thesis titled "Analysis and prediction of solvent accessibility in proteins, and hot spots in protein-protein interaction". He graduated in Informatics Engineering at the University of Modena and Reggio Emilia in 2007 with a thesis titled "InSite: project and implementation of an auxiliary software tool for prediction of interaction sites in proteins".

His research interests include Bioinformatics, Computational Biology and Drug Design. Although these encompass a wide range of interdisciplinary techniques, his research is mainly focused on the computational characterisation of protein-protein interfaces by designing and using Bioinformatics applications and software tools.

Further information is available in my CV.

Research Activity

The main goal of the doctorate research activity is the development of algorithms to be applied at software tools to solve problems inspired by biology. The main problems I'm investigating are:

• Sequence-based Prediction of Protein-Protein Solvent Accessibility

  Development of a method for accurate prediction of protein residues solvent accessibility using sequence homology information and descriptors of physical-chemical properties of amino acids. Solvent Accessibility prediction is an intermediate step to Protein-Protein Interaction sites prediction.

• Structural Bioinformatics

  Organisation of sequence, structure and functional data in relational databases of three-dimensional structures of proteins and their interactions (CREDO, PICCOLO databases). Analysis of Hot Spots for interaction sites in Protein-Protein Interaction.

• Extraction of Structured Motifs from DNA sequences

  The goal of this research project is the development of an exact algorithm that discovers structured motifs (groups of simple motifs occurring relatively near each other) in DNA sequences.

Papers

Workshops

Conferences